The efficacy of probiotics in experimental autoimmune encephalomyelitis (an animal model for MS): a systematic review and meta‐analysis

Probiotics immunomodulatory properties and their beneficial effects for diseases such as multiple sclerosis (MS) are reported by several studies. The current systematic review meta-analysis aimed to investigate the favourable of probiotics in improving experimental autoimmune/allergic encephalomyelitis (EAE) an animal model MS. We systematically searched Scopus, Web Sciences (ISI), PubMed databases identify relevant studies from inception these December 2019. A total 15 met inclusion criteria, while no human study criteria. association between consumption each sign was calculated using producing pooled odd ratios (95% confidence interval [95% CI]) a random effect model. revealed significant on incidence EAE, weight gain, clinical symptoms. However, duration disease varied probiotic strain. administration associated with reduction risk mortality only female animals. Moreover, promising prevention management EAE.